Secondary Pituitary Hypofunction - CMC

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Endocrinologie Urologie

Secondary Pituitary Hypofunction

The disorder known as secondary hypogonadism, also known as secondary pituitary hypofunction, is characterized by insufficient levels of the hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which stimulate the testes to create testosterone. Many symptoms, such as diminished libido, erectile dysfunction, weariness, and decreased muscle mass, may result from this.

The most common cause of secondary pituitary hypofunction

is a pituitary tumor or other damage to the pituitary gland. Other causes include certain medications, such as steroids, and radiation therapy to the head.

Treatment for secondary pituitary hypofunction

typically involves hormone replacement therapy, which can help to alleviate symptoms and improve quality of life.

Other hormones, such as LH and FSH, may also be taken in addition to testosterone replacement therapy to assist in stimulating the testes to make testosterone. If a pituitary tumor is what’s causing the hypofunction, other treatment choices can include surgery or radiation therapy.


Secondary pituitary hypofunction can be caused by various factors, including pituitary tumors, pituitary surgery or radiation therapy, head trauma, genetic disorders, autoimmune conditions, infections, certain medications, and vascular disorders affecting the pituitary gland.

The symptoms of secondary pituitary hypofunction depend on which hormones are deficient. Common symptoms can include fatigue, weight loss or gain, low blood pressure, decreased libido, infertility, menstrual irregularities, cold intolerance, sluggishness, and changes in appetite or mood.

Secondary pituitary hypofunction may not be reversible or curable in all cases, especially if the underlying cause is irreversible damage to the pituitary gland. However, with appropriate hormone replacement therapy, symptoms can be effectively managed, and individuals can lead normal and fulfilling lives.

Secondary pituitary hypofunction is relatively rare compared to other endocrine disorders. The prevalence may vary depending on the underlying causes, such as pituitary tumors or head trauma. Overall, it is considered a less common condition.

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